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Below is a partial list of references of the research on Polydatin
References for Polydatin
1: Huang K, Chen C, Hao J, Huang J, Wang S, Liu P, Huang H. Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to
resist AGEs-induced upregulation of fibronetin and transforming growth factor-β1 in rat glomerular messangial cells. Mol Cell Endocrinol. 2014
Sep 2.
2: Ding W, Dong M, Deng J, Yan D, Liu Y, Xu T, Liu J. Polydatin attenuates cardiac hypertrophy through modulation of cardiac Ca2+ handling and
calcineurin-NFAT signaling pathway. Am J Physiol Heart Circ Physiol. 2014 Sep 1;307(5):H792-802.
3: Wen H, Gao X, Qin J. Probing the anti-aging role of polydatin in Caenorhabditis elegans on a chip. Integr Biol (Camb). 2014 Jan;6(1):35-43.
4: Zhang Y, Zhuang Z, Meng Q, Jiao Y, Xu J, Fan S. Polydatin inhibits growth of lung cancer cells by inducing apoptosis and causing cell cycle
arrest. Oncol Lett. 2014 Jan;7(1):295-301.
5: Du QH, Peng C, Zhang H. Polydatin: a review of pharmacology and pharmacokinetics. Pharm Biol. 2013 Nov;51(11):1347-54.
6: De Maria S, Scognamiglio I, Lombardi A, Amodio N, Caraglia M, Cartenì M, Ravagnan G, Stiuso P. Polydatin, a natural precursor of resveratrol,
induces cell cycle arrest and differentiation of human colorectal Caco-2 cell. J Transl Med. 2013 Oct 20;11:264.
7: Yang B, Li JJ, Cao JJ, Yang CB, Liu J, Ji QM, Liu ZG. Polydatin attenuated food allergy via store-operated calcium channels in mast cell. World J
Gastroenterol. 2013 Jul 7;19(25):3980-9
8: Jiang X, Liu W, Deng J, Lan L, Xue X, Zhang C, Cai G, Luo X, Liu J. Polydatin protects cardiac function against burn injury by inhibiting
sarcoplasmic reticulum Ca2+ leak by reducing oxidative modification of ryanodine receptors. Free Radic Biol Med. 2013 Jul;60:292-9.
9: Wang X, Song R, Chen Y, Zhao M, Zhao KS. Polydatin--a new mitochondria protector for acute severe hemorrhagic shock treatment. Expert
Opin Investig Drugs. 2013 Feb;22(2):169-79.
10: Chen L, Lan Z, Lin Q, Mi X, He Y, Wei L, Lin Y, Zhang Y, Deng X. Polydatin ameliorates renal injury by attenuating oxidative stress-related
inflammatory responses in fructose-induced urate nephropathic mice. Food Chem Toxicol. 2013 Feb;52:28-35.
11: Ravagnan G, De Filippis A, Cartenì M, De Maria S, Cozza V, Petrazzuolo M, Tufano MA, Donnarumma G. Polydatin, a natural precursor of
resveratrol, induces β-defensin production and reduces inflammatory response. Inflammation. 2013
Feb;36(1):26-34.
12: Hosoda R, Kuno A, Hori YS, Ohtani K, Wakamiya N, Oohiro A, Hamada H, Horio Y. Differential cell-protective function of two resveratrol
(trans-3,5,4'-trihydroxystilbene) glucosides against oxidative stress. J Pharmacol Exp Ther. 2013 Jan;344(1):124-32.
13: Baek SH, Shin WC, Ryu HS, Lee DW, Moon E, Seo CS, Hwang E, Lee HS, Ahn MH, Jeon Y, Kang HJ, Lee SW, Kim SY, D'Souza R, Kim HJ, Hong
ST, Jeon JS. Creation of resveratrol-enriched rice for the treatment of metabolic syndrome and related diseases. PLoS One. 2013;8(3):e57930.
14: Xie X, Peng J, Huang K, Huang J, Shen X, Liu P, Huang H. Polydatin ameliorates experimental diabetes-induced fibronectin through inhibiting
the activation of NF-κB signaling pathway in rat glomerular mesangial cells. Mol Cell Endocrinol. 2012 Oct 15;362(1-2):183-93
15: Zhang J, Tan Y, Yao F, Zhang Q. Polydatin alleviates non-alcoholic fatty liver disease in rats by inhibiting the expression of TNF-α and SREBP-
1c. Mol Med Rep. 2012 Oct;6(4):815-20.
16: Liu LT, Guo G, Wu M, Zhang WG. The progress of the research on cardio-vascular effects and acting mechanism of polydatin. Chin J Integr
Med. 2012 Sep;18(9):714-9.
17: Shi YW, Wang CP, Liu L, Liu YL, Wang X, Hong Y, Li Z, Kong LD. Antihyperuricemic and nephroprotective effects of resveratrol and its
analogues in hyperuricemic mice. Mol Nutr Food Res. 2012 Sep;56(9):1433-44
18: Li RP, Wang ZZ, Sun MX, Hou XL, Sun Y, Deng ZF, Xiao K. Polydatin protects learning and memory impairments in a rat model of vascular
dementia. Phytomedicine. 2012 Jun 15;19(8-9):677-81
19: Wang X, Song R, Bian HN, Brunk UT, Zhao M, Zhao KS. Polydatin, a natural polyphenol, protects arterial smooth muscle cells against
mitochondrial dysfunction and lysosomal destabilization following hemorrhagic shock. Am J Physiol Regul Integr Comp Physiol. 2012
Apr;302(7):R805-14
20: Lanzilli G, Cottarelli A, Nicotera G, Guida S, Ravagnan G, Fuggetta MP. Anti-inflammatory effect of resveratrol and polydatin by in vitro IL-17
modulation. Inflammation. 2012 Feb;35(1):240-8
21: Ji H, Zhang X, Du Y, Liu H, Li S, Li L. Polydatin modulates inflammation by decreasing NF-κB activation and oxidative stress by increasing Gli1,
Ptch1, SOD1 expression and ameliorates blood-brain barrier permeability for its neuroprotective effect in pMCAO rat brain. Brain Res Bull.
2012 Jan 4;87(1):50-9.
22: Miao Q, Shi XP, Ye MX, Zhang J, Miao S, Wang SW, Li B, Jiang XX, Zhang S, Hu N, Li J, Zhang J. Polydatin Attenuates Hypoxic Pulmonary
Hypertension and Reverses Remodeling through Protein Kinase C Mechanisms. Int J Mol Sci.
2012;13(6):7776-87.
23: Miao Q, Wang S, Miao S, Wang J, Xie Y, Yang Q. Cardioprotective effect of polydatin against ischemia/reperfusion injury: roles of protein
kinase C and mito K(ATP) activation. Phytomedicine. 2011 Dec 15;19(1):8-12.
24: Sheng C, Yu YH, Zhao KS, Qin W, Wang CH. Hypotensive resuscitation combined with polydatin improve microcirculation and survival in a
rabbit model of uncontrolled hemorrhagic shock in pregnancy. J Surg Res. 2011 Jun 1;168(1):103-10.
25: Yao J, Wang JY, Liu L, Zeng WS, Li YX, Xun AY, Zhao L, Jia CH, Feng JL, Wei XX, Wang LS. Polydatin ameliorates DSS-induced colitis in mice
through inhibition of nuclear factor-kappaB activation. Planta Med. 2011 Mar;77(5):421-7.
26: Zhang LP, Wei Y, Song SL, Cheng M, Zhang Y. Effect of polydatin on action potential in ventricular papillary muscle of rat and the underlying
ionic mechanism. Sheng Li Xue Bao. 2011 Feb 25;63(1):48-54.
27: Gao JP, Chen CX, Gu WL, Wu Q, Wang Y, J. Effects of polydatin on attenuating ventricular remodeling in isoproterenol-induced mouse
and pressure-overload rat models. Fitoterapia. 2010 Oct;81(7):953-60.
28: Jeong ET, Jin MH, Kim MS, Chang YH, Park SG. Inhibition of melanogenesis by piceid isolated from Polygonum cuspidatum. Arch Pharm Res.
2010 Sep;33(9):1331-8.
29: Zhang LP, Ma HJ, Bu HM, Wang ML, Li Q, Qi Z, Zhang Y. Polydatin attenuates ischemia/reperfusion-induced apoptosis in myocardium of the
rat. Sheng Li Xue Bao. 2009 Aug 25;61(4):367-72.
30: Xing WW, Wu JZ, Jia M, Du J, Zhang H, Qin LP. Effects of polydatin from Polygonum cuspidatum on lipid profile in hyperlipidemic rabbits.
Biomed Pharmacother. 2009 Aug;63(7):457-62.
31: Zhou S, Yang R, Teng Z, Zhang B, Hu Y, Yang Z, Huan M, Zhang X, Mei Q. Dose-dependent absorption and metabolism of trans-polydatin in
rats. J Agric Food Chem. 2009 Jun 10;57(11):4572-9.
32: Rivière C, Delaunay JC, Immel F, Cullin C, Monti JP. The polyphenol piceid destabilizes preformed amyloid fibrils and oligomers in vitro:
hypothesis on possible molecular mechanisms. Neurochem Res. 2009 Jun;34(6):1120-8.
33: Du J, Sun LN, Xing WW, Huang BK, Jia M, Wu JZ, Zhang H, Qin LP. Lipid-lowering effects of polydatin from Polygonum cuspidatum in
hyperlipidemic hamsters. Phytomedicine. 2009 Jun;16(6-7):652-8
34: Fabris S, Momo F, Ravagnan G, Stevanato R. Antioxidant properties of resveratrol and piceid on lipid peroxidation in micelles and
monolamellar liposomes. Biophys Chem. 2008 Jun;135(1-3):76-83.
35: Zhang LP, Yang CY, Wang YP, Cui F, Zhang Y. Protective effect of polydatin against ischemia/reperfusion injury in rat heart. Sheng Li Xue
Bao. 2008 Apr 25;60(2):161-8.
36: Kerem Z, Bilkis I, Flaishman MA, Sivan L. Antioxidant activity and inhibition of alpha-glucosidase by trans-resveratrol, piceid, and a novel
trans-stilbene from the roots of Israeli Rumex bucephalophorus L. J Agric Food Chem. 2006 Feb
22;54(4):1243-7.
37: Zhao Q, Huang HX, Jin CH. Protective effect of polydatin against lipopolysaccharide-induced myocardial injury. Di Yi Jun Yi Da Xue Xue Bao.
2003 Apr;23(4):364-6
38: Zhao KS, Jin C, Huang X, Liu J, Yan WS, Huang Q, Kan W. The mechanism of Polydatin in shock treatment. Clin Hemorheol Microcirc.
2003;29(3-4):211-7.
39: Romero-Pérez AI, Ibern-Gómez M, Lamuela-Raventós RM, de La Torre-Boronat MC. Piceid, the major resveratrol derivative in grape juices.
J Agric Food Chem. 1999 Apr;47(4):1533-6.
40: Huang ZS, Wang ZW, Liu MP, Zhong SQ, Li QM, Rong XL. Protective effects of polydatin against CCl(4)-induced injury to primarily cultured
rat hepatocytes. World J Gastroenterol. 1999 Feb;5(1):41-44